Clinical Trials Search
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A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)
This study is being done to learn more about the effectiveness and safety of VX445/tezacaftor (TEZ)/ivacaftor (IVA) in patients with cystic fibrosis.
- Status: Not-Recruiting
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A Pilot Study of Combined Immune Checkpoint Inhibition in combination with ablative therapies in Subjects with Hepatocellular Carcinoma (HCC)
To preliminarily evaluate the 6-month progression free survival (PFS) of combining tremelimumab and durvalumab in patients with advanced HCC (in combination with TACE).
- Status: Not-Recruiting
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A Study Evaluating the Long-term Safety and Efficacy of Vx-659 Combination Therapy
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-659 Combination Therapy in Subjects with Cystic Fibrosis who are Homozygous or Heterozygous for the F508del Mutation
- Status: Open Recruiting
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Acute and Chronic effects of CFTR Modulation on CF Pathophysiology.
The purpose of this study is to test the effect of a CFTR Correctors on Pseudomonas aeruginosa (Pa) or Staphylococcus aureus (Sa) in the sputum of Cystic Fibrosis (CF) patients with certain genotypes.
- Status: Not-Recruiting
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An International, Multicentre, Randomised Controlled Pragmatic Trial of Mirtazapine to alleviate Breathlessness in Palliative and End of Life Care.
The trial is to assess the effectiveness and cost-effectiveness of mirtazapine for the reduction of patient-reported chronic or refractory breathlessness and quality of life in patients with COPD or ILD and at end of life, and on the caregiver burden, quality of life and experience of their lay caregivers and close family members.
- Status: Open Recruiting
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Convince
To Reduce the risk of another stroke patients are randomized to usual care or low dose Colchicine.
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COVIRL-002
Key Eligibility Criteria Aged 18 years or older Inpatient hospitalisation Confirmed SARS-CoV2(COVID-19) Infection Evidence of hyper-inflammatory state and pulmonary infiltrates on chest imaging. Moderate to severe respiratory failure.
- Status: Open Recruiting
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EUROPA T-DXd – EUropean Real-world experience of previously treated advanced/metastatic HER2-positive breast cancer patients accessing trastuzumab deruxtecan through a named patient programme
This study is being done to collect and analyse demographic data, clinical characteristics and efficacy of treatment of T-DXd in patients with advanced/metastatic HER2-positive breast cancer
- Status: Open Recruiting
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HS0004
Evaluate the efficacy of bimekizumab in study participants with moderate to severe HS
- Status: Closed
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IMPALA – 2
The aim of this trial is to confirm if Molgramostim Nebulizer Solution (inhaled molgramostim) improves function of the lungs in patients with autoimmune pulmonary alveolar proteinosis (aPAP).
- Status: Open Recruiting
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LAPTOP (The Late Presenter Treatment Optimisation Study)
To compare two different types of HIV treatments, in terms of effectiveness and improvement of side effects, for patients who are diagnosed with a more advanced HIV infection.
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Phase 3, Open-label Study Evaluating the Long-term Safety of VX445 Combination Therapy in Subjects with Cystic Fibrosis
This study is being done to learn more about the safety and tolerability of the combination of elexacaftor (VX-445), TEZ and IVA in patients with CF.
- Status: Not-Recruiting